It should take you approximately 15 seconds into the above trailer for you to say to yourself, "Okay. This is a little weird." The Zeno Clash series feel like something right out of Tim Burton's imagination.
Character designs prominently feature odd human-animal hybrids, like boar people that squeal like an injured pig when attacked. Even the more humanoid characters, such as your main character, have odd proportions and unsettling features. Seriously, what the heck is up with the protagonist's haircut?
The below is from Zeno Clash 1's Wikipedia page:
The game commences with Ghat, the game's protagonist, regaining consciousness after setting off an explosion which kills Father-Mother, an ostensibly hermaphroditic creature, which has raised a large and influential family.
The beginning of the game really helps set the tone for the game to come.