When all else fails, and the system works right, you can rely on your Pathfinder's RSF (Resting Stoned Face) to destroy the moment. It's the sorta face you'd make after taking your first hit off of some wacky tobacky and having your mom walk in your room. It's not so noticeable that she knows you're high, but it's bad enough that she knows something is... off. And that's the way I always feel about Sara Ryder.
So there you have it. There's a variety pack of some of the times that ME:A decided that immersion wasn't a primary goal of theirs. I wish I could say that I was just cherry picking and that these sorts of things only happen once in awhile, but more often than not a character is acting weird or clipping through something. And if they aren't screwing up, the camera decides to fill in for them.