Mutant City Blues' story is remarkably similar to Heroes, that television program involving several people with superpowers. Where it differs, however, is the fact the protagonists are actually detectives, policing the streets of a world forever changed by mutant powers. While it might only be 1% of the population, that single percentage point is presumably enough to wreak considerable havoc, and the mutated adversaries featured within are definitely troublesome. People can read minds, travel through walls, shoot energy and even fly. What's not to like?
The player's squad is equally as mutated as the various denizens of the metropolis. And whenever any mutation-related killing occurs, the detectives are on the case, utilizing their mysterious super powers to even the odds. Players are capable of using genealogy to uncover who is potentially a mutant by using a clever diagram, linking powers together. Investigating residue from grisly murders and similar forensics is also possible using advanced technology, demonstrating this experience is both about high-tech goodness and incredible super powers -- a match made in heaven.
Mutant City Blues uses the GUMSHOE system, which is a system specifically designed for investigative approaches. It ensures a more frenetic approach than some systems and easily allows game masters a simplistic method for writing and running various scenarios. It always provides enough investigative information to be compelling, and that nearly always leads to a compelling ending to a case.