Another game that surprisingly didn't make the cut, River City Ransom is a game that is likely better remembered for its memes nowadays than it is as a game.
River City Ransom was originally released back in 1989, and was a well-known open world action, role-playing, beat 'em up game for the NES and Famicom. The game featured really silly spritework, as well as captions for every scene in the game. If you beat up a character they'd respond with lines like "Barf!" or "Mamaaa!" while they would taunt you in turn if they hit you.
This NES classic is truly something that has to be played to appreciate. Sadly, it looks like we'll have to stick to playing the game on the Wii U and 3DS virtual console.