There's more than horror games on this list, I promise.
This title went widely unnoticed by the general gaming community and was received by the critics with lukewarm fanfare. Nonetheless, it provided a more than decent survival-horror experience on the PlayStation 2.
The player controls Dennis Riley, a U.S. Marine who, together with his partner Roger, must infiltrate a secret research base in Antarctica after receiving a distress signal. Extermination plays out similarly to other games in the genre, such as Dino Crisis and Resident Evil.
The game features a predictable storyline and a glut of cheesy dialogue, but it's redeemed by great sound design and atmosphere, heavily resembling John Carpenter's movie The Thing.
It was among the first titles on PlayStation 2 and was used to showcase the console's capabilities, therefore selling reasonably well for the time. Alas, a sequel is highly unlikely, though one can dream.