Comic by: Halorith
Diseases in RPGs are often based on real life ailments. Why create something brand new when we have such a long list of ailments to choose from? It would be difficult to imagine anything worse than what humans already suffer with.
For instance, Ataxia is actually a neurological symptom characterized by loss of control over voluntary movements. Those suffering from Ataxia may have trouble buttoning their shirts, using eating utensils or using a keyboard. This is closely aligned with Skyrim's Ataxia debuff, which lowers the player's pick pocketing and lock picking abilities.
Real life Ataxia is caused by severe head trauma, often from car accidents, so it's easy to see how the Dragonborn might end up with the debuff.