Not exactly Mass Effect 4, this game still has a huge fanbase anxiously awaiting its arrival. The "sequel" to the original trilogy takes place quite sometime after the events of the third installment, and doesn't feature the original cast, nor the original galaxy. Slated for release this holiday season, this reboot could change the entire nature of the Mass Effect series - and that, my friends, is the problem it's going to have to face.
There are some hardcore fanboys of the Mass Effect series out there; people who have dedicated significant portions of their lives to the games. If Andromeda wants to have a chance it will have to pay so much homage to the original series, they might as well have announced a legitimate Mass Effect 4.
Unless EA and BioWare can make this game as close to perfect as possible, fans will completely dismiss it and chances for further sequels will be trashed.
Starting up a new series in the same universe as far as Mass Effect goes is a gamble. The reward could be outstanding, but is it worth the risk? I guess we'll find out this Christmas.