DC movies and games are known for being dark in tone, but when we're talking about a bunch of misfit psychos, it might help to lighten up from time to time.
The Suicide Squad video game could really stand out in the genre with a few well-placed jokes and optimistic quips. If you take a heavy subject and make it even heavier, a Suicide Squad video game could get really depressing.
Keep it funny, keep it fun. Your fans will thank you for the imagination.