God Hand puts players in the role of Gene, a martial artist who is bestowed with one of the legendary "God Hands", a pair of divine arms that were once used to save the world from a demon called Angra. Gene and his companion Olivia are eventually caught up in an attempt by a group of demons known as the Four Devas to resurrect Angra for purposes of world domination. The game mixes western and Japanese-themed comedy, containing over-the-top characters and storyline events. The gameplay combines traditional elements of the beat 'em up genre with new features. These include being able to map and string together a large repertoire of fighting techniques to the gamepad's face buttons in order to create unique combo attacks.