BioShock series is a perfect candidate for being turned into a few high-budget Hollywood blockbusters with some nice plot. At one point such a movie was greenlit, but due to financial problems and artistic differences it was put on a halt indefinitely.
Fortunately, there are some really cool short films based on the iconic game. One of them is The Brothers Rapture created by film students from Canada. It tells the story of two brothers who work in the Rapture City and how their experiments lead to some horrific results.