Continuing with the Americana theme, the southern United States is ripe with potential locations for a Fallout 4 mod. Little is actually known about the southern United States in the Fallout universe compared to the East and West Coasts. And it doesn't get much more quintessentially southern than New Orleans.
Fallout 3's "Point Lookout" DLC gave us a small taste of what a swamp environment might look like in the Wasteland. But I want to see more. And the unique city of New Orleans -- not to mention the surrounding bayou -- are prime territory for modders to let their creativity fly and interpret a brand new location.
Even better, the potential for factions down South could be vastly different from those we've seen on the East or West Coast. Chances are we wouldn't see the Brotherhood of Steel, as they have no records of traveling down South. And the NCR has been too busy expanding in the West to worry about Old Dixie.
Everything about this location -- the environment, faction possibilities, unique wildlife, and new mutant opportunities -- screams for modders to take advantage.