Why this works:
Like any good adventure game, there is plenty of mystery driving the plot of the movie The Fugitive. In this case, there is one important mystery that needs to be solved: Who set up Doctor Richard Kimble?
Not only does this give the story an emotional core, but it also allows for Telltale to include another protagonist: Samuel Gerard, the US Marshal hunting Kimble, who is convinced for most of the movie that he is guilty.
Not only does this give the player some interesting character interactions, but it also allows them to see the how choices one character affects the other immediately.