What do you do when you are pulled into an otherworldly arena, and forced to do battle against demons, angels, aliens, and magical creatures? If you're Sgt. Bama "the Hammer" Kowalski, blow them to hell with your Crucio-Class Siege Tank, that's what!
While Sgt. Hammer isn't exactly the most impressive gal on our list in terms of enemies killed, she does sport some impressive firepower and destructive capabilities. Just about everyone and everything that gets in the way of her siege tank is dead. This is without mentioning her arsenal including: spider mines, arclite siege cannons, her blunt force gun, and good ol' napalm strikes.
As a result, Sgt. Hammer climbs the ranks and demolishes the previous gun-girls with a #5 standing.