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This tips guide for Siege of Centauri will show which towers and defenses are best against each type of alien invader.

Siege of Centauri Guide: Enemy Strategy Guide

This tips guide for Siege of Centauri will show which towers and defenses are best against each type of alien invader.
This article is over 5 years old and may contain outdated information

There are several ways to play tower defense game Siege of Centauri, but whether it’s Campaign mode or Endless mode, both beginners and veterans are thrown into the heat of the battle right away.  

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While veterans should quickly understand the concepts at play, newcomers might drown under the game’s vast number of weapons, enemies, and strategies.

So, to avoid that fate, we’ve put together this beginner’s guide for Siege of Centauri. The tips below will help you learn how to fight and destroy hordes of aliens in the most effective ways possible.

We’ll cover: 

  • Best strategies against Frigates
  • Best strategies against Cruisers
  • Best strategies against Air Units
  • Best strategies against Dreadnoughts and Juggernauts

Every mission in Siege of Centauri starts with intelligence gathering, where you learn what types of enemies will attack your base and from which direction(s).  After this phase, you are given time to build and place weaponry as you see fit.

If you choose wisely, then defending your position should be easy. But to be sure, here’s how you gain the advantage against your enemies. 

Best Strategies Against Frigates

A masochist enemy unit shown in a Siege of Centauri menu

There are seven types of enemy frigates in Siege of Centauri. Each has its weaknesses and strengths, which you can utilize to defeat them.

Here are the best weapon strategies against each enemy frigate type:

vs. Masochists
  • Rail Guns with Shotgun upgrade
  • Drone Bays on large maps
  • Pulse Cannons
  • Mortars and Arc Projectors in large quantities
vs. Capacitors
  • Arc Projectors with Shotgun upgrade
  • Rail Guns with Shotgun upgrade
  • Artillery Post with Incendiary Payload upgrade
vs. Reapers
  • Gun Turrets with Shotgun upgrade
  • Arc Projectors
  • Mortars
  • Milton’s Missile Attacks
vs. Scarabs
  • Mortars
  • Artillery Posts
  • Arc Projectors with Chain Lightning upgrade
  • Corrosion Mortars with Contagious Virus upgrade
  • Minos Cannon with Lure of the Volatile Reaction upgrade
vs. Martyrs
  • Nova Cannon
  • Artillery Posts
  • Reinforcements
vs. Corrupted Healers
  • Mortars
  • Artillery Posts
  • Rail Guns
  • Particle Lasers
  • Corrosion Mortars
vs. Hatchlings
  • Mortars
  • Arc Projectors
  • Shotguns
  • Artillery Posts

Best Strategies Against Cruisers

A destructor shown in a Siege of Centauri menu

Cruisers are the most frequent enemies you will face. There are nine types of enemy cruisers in the game.

Cruisers can become very dangerous in large numbers, so be sure to use these strategies against each type:

vs. Destructors
  • Corrosion Mortars
  • Particle Lasers
  • Minos Cannon with Overcharging upgrade
vs. Falling Stars
  • Ion Disrupters
  • Corrosion Mortars
  • Minos Cannon with Overcharging upgrade
vs. Eradicators
  • Particle Lasers
  • Nova Cannons
  • Upgraded EMP Blast
  • Pulse Cannons
vs. Hooded Turbines
  • Ion Disrupters
  • Pulse Cannons with Colony Pulse upgrade
  • Corrosion Mortars
vs. Mobile Nullifiers
  • Particle Lasers
  • Ion Disrupters
vs. Rolling Hives
  • Disruption Beam
  • Flak Cannons
  • Rail Guns with Shotgun Upgrade
vs. Floating Factories
  • Minos Cannons
  • Corrosion Mortars
  • Pulse Cannons
vs. Taskmasters
  • Gravity Wells
  • EMP
  • Disruption Beam
vs. Clutch of Eggs
  • Minos Cannon with Violent Overload upgrade
  • Corrosion Mortars

Best Strategies Against Air Units

A punisher shown in a Siege of Centauri menu

Until now, we’ve been focusing on terrain units, but there is also a large number of air units that attack from above.

Currently, there are five different types of air units, and each requires a different kind of strategy.

vs. Punishers
  • Falcons
  • Icarus SAMs
vs. Sparrows
  • Anti-Air Turrets
  • Arc Projector with Storm Projector upgrade
vs. Harbingers
  • Icarus SAMs
  • Disruption Beam
  • Reinforcements
vs. Vultures
  • Rail Guns
  • Disruption Beam
vs. Gliding Cranes
  • Icarus SAM with Overcharging upgrade
  • Scavenger Modules

Best Strategies Against Dreadnoughts and Juggernauts

An overmind shown in a Siege of Centauri menu

Lastly, the most dangerous types of enemies are dreadnoughts and juggernauts. These massive machines can single-handedly destroy your base if you don’t have a pre-planned strategy against each of them.

vs. Overminds
  • Ion Disrupters
  • Minos Cannons
  • Pulse Cannon with Disruption upgrade
vs. Retributors
  • Ion Cannon with Defense Scrambling upgrade
  • Particle Lasers
  • Gravity Wells
  • Stasis Hammers
  • Amplifiers
vs. Nest of the Queen
  • Minos Cannons
  • Ion Cannon with Defense Scrambling upgrade
  • Particle Lasers with Graviton Beam upgrade
  • EMP
  • Temporal Shift
vs. Heart of the Phoenix
  • Nova Cannon with Field Leak upgrade
  • Particle Lasers
  • Gravity Wells
  • Stasis Hammers
  • Temporal Shift

These are the best strategies for each enemy type of Siege of Centauri. For more on the game, be sure to head over to our official review

Siege of Centauri is currently available on Steam for PC. 


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Serhii Patskan
Serhii is the Writer at GameSkinny. He's been writing for GameSkinny since 2015. Before that, he's been writing for various outlets and playing video games, which eventually turned into a passion. The video games that have contributed the most to his enthusiasm for writing about this industry are Magic: The Gathering, Dark Souls, and The Elder Scrolls V: Skyrim.