Both Prototype and it's sequel Prototype 2 gave their players excellent murder playgrounds to frolic around in. Which isn't that surprising, as you'd probably expect the same developer as The Simpsons: Hit & Run, to understand chaotic gameplay pretty well.
There isn't much to say about the gameplay of the Prototype series, as the two games are very similar, and the gameplay is pretty simple, but just deep enough to be involving and challenging.
Both Prototype games are highly visceral murder-centric sandboxes that guide the player through a sinister conspiracy plot unfolding in New York City. The protagonist becomes unwillingly involved and is turned into a super-powered mutant with killer superpowers.
The story isn't the best in either installment, although that isn't for a lack of trying. It's mostly because it's too difficult to rationalize all of the horrible things that the protagonists do to really call them heroes.
Both Alex Mercer and James Heller are more villains or anti-heroes than traditional heroes. But if this was necessary in order to allow the player the previously mentioned freedom in gameplay, I'd call it a fair sacrifice.
You are free to kill, maim, and cause property damage in a number of wonderfully creative, and most importantly -DESTRUCTIVE ways- Everything from disguising yourself as a soldier by eating one alive, to hijacking tanks and helicopters with your tentacle arm, to even turning human enemies into bombs and throwing them into a huge crowd to watch everything get pulled into them before exploding.
Prototype 2 improved on a lot of the minor flaws found in the first game, by improving on the slightly frustrating controls, changing the upgrade system, and making the sandbox a great deal larger with much more colorful and high-end graphics. Despite these obvious improvements, both games are different enough from each other to be worth playing, and are both easily recommendable.
It's a true shame that Activision closed Radical Entertainment's doors even after Prototype 2's excellent sales, but if nothing else, Prototype 2 was a great game and a great swan song for an overall great developer.
Take a peek below at how fun it can be to murder your maker: