Spec Ops: The Line was pure genius. The game ensured players felt like sick, demented individuals for partaking in the sequences throughout -- all the while telling an interesting, compelling story of the darkness that ensues during wartime.
One sequence, however, stands apart from the rest. The end speech brought to you by Konrad literally calls the player out for empowering themselves by playing video games. Granted, the in-game character was originally speaking to Captain Walker, but the developer ensured it felt fourth wall-breaking, too.