Diablo 4 Alabaster Monastery entrance
Screenshot by GameSkinny

Diablo 4: Blood Sermon Side Quest Walkthrough

Here's our complete guide to the Blood Sermon side quest in Diablo 4.

The Diablo 4 Blood Sermon quest puts you to task. Sanctuary is plagued by evil andits people are susceptible to bad decisions. Sister Vera near the Sanguine Chapel will ask for your help when she learns of the dark confessions of a dying Knight, giving you the Blood Sermon side quest. Here you’ll find our complete guide to the Diablo 4 Blood Sermon side quest.

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Diablo 4 Blood Sermon Guide

Diablo 4 Blood Sermon side quest Sister Vera and Sanguine Chapel map location
Screenshot by GameSkinny

To begin the quest, head to Kor Valar in Fractured Peaks and speak to Sister Vera. The location is northeast of Kyovashad, and marked on the map above. I knew after speaking to her I’d be in for some demon fighting, and I wasn’t disappointed.

  • Sister Vera will tell you to go to the Sanguine Chapel, a dungeon underneath the Alabaster Monastery, and retrieve the Red Chalice from the Bishop. The Chapel is southeast of Sister Vera, and is marked on the map above.
Diablo 4 Blood Sermon side quest Sanguine Chapel mechanical box pedestals door
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  • Once you enter the Sanguine Chapel dungeon you’ll need to return two Mechanical Boxes to the Pedestals at the interior doors to proceed.
Diablo 4 Blood Sermon side quest Sanguine Chapel first mechanical box location
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  • The first Mechanical Box is found northeast of the doors, and you’ll need to defeat Sobek, a Vampiric, Teleporter, and Suppressor, to get it. 
  • After you defeat Sobek and get the Box, head back to the doors and place it on one of the pedestals.
Diablo 4 Blood Sermon side quest Sanguine Chapel second mechanical box location
Screenshot by GameSkinny
  • The second Mechanical Box is found southeast of the doors, and you’ll need to defeat Vadim, a Vampiric, Plaguebearer, Poison Enchanted, to get it.
  • After you defeat Vadim and get the Box, head back to the doors and place it on the remaining pedestal.
Diablo 4 Blood Sermon side quest Sanguine Chapel blood wall
Screenshot by GameSkinny
  • When the doors open, you’ll need to defeat all enemies in the new area, the Defiled Undercroft. You’ll know how many are left by checking the right side of your screen.
  • After defeating all enemies in the Defiled Undercroft, enter the final area that was hidden by the blood wall. There, you’ll find the final quest boss, the Blood Bishop.
Diablo 4 Blood Sermon side quest Sanguine Chapel Blood Bishop final boss.
Screenshot by GameSkinny
  • Avoid the bloody tentacles as you fight the Blood Bishop.
  • Once you defeat him, you’ll unlock an Energizing Aspect for completing the dungeon, and be able to retrieve the Red Chalice.
Diablo 4 Blood Sermon side quest Sister Vera final map location at the Bear Tribe Refuge
Screenshot by GameSkinny
  • Take the Red Chalice back to Sister Vera, she’s now located at the Bear Tribe Refuge that’s northwest of the Sanguine Chapel, and it’s marked on the map above.
  • You’ll be rewarded an item Cache, gold, and XP tailored to your level.

Well, that’s it for our guide on the Diablo 4 Blood Sermon side quest. For more tips, tricks, and walkthroughs, check out our Diablo 4 guides hub here.


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Author
Maddison Ahlbrand
Maddison started her gamer journey traversing the lands of Runescape and World of Warcraft. These days, she can be found playing just about anything, but a lot of her free time is spent playing FPS games like Fortnite, CoD and Valorant. She's been with GameSkinny since February 2023, and has a BA in Art History.