If you have the cash and want to buy the most expensive nightclub in the After Hours DLC, it would still be better to buy the Downtown Vinewood club, which is just a pinch cheaper.
After all, it is located in the northern part of the city, which is a huge plus, since this is where most of the missions take place. This makes it incredibly convenient for aircraft landing, while the main garage door gives you access to both north and south roads.
However, there is one thing that might make you look out for another club and that's an awfully dirty location with several dumpsters around. So if this is somehow a factor for you, then you should consider it before buying the Downtown Vinewood club.